With Mixon once again sidelined during on-field drills this week, it appears likely that Giovani Bernard will start his second straight game.
Mixon, Cincinnati's starting tailback, injured his foot in Week 6 versus the Indianapolis Colts and hasn't practiced since.
In his absence, Bernard carried the ball 13 times for 37 yards in a Week 8 loss to the Cleveland Browns, adding five receptions for 59 yards.
The Bengals face the Tennessee Titans on Sunday before entering a bye in Week 9.
Mixon has rushed for 428 yards and three touchdowns through six games this season. He also caught 21 passes for 138 yards and one score.